Research Articles
COG Database 2024: A Comprehensive Guide to Functional Categorization of Bacterial Genomes for Biomedical Research
This article provides a comprehensive overview of the COG (Clusters of Orthologous Genes) database, a pivotal resource for phylogenetic classification and functional annotation of prokaryotic proteins.
Advanced Strategies for Contig Binning of Closely Related Microbial Strains
Resolving closely related strains in metagenomic samples is a significant challenge in microbial genomics, with implications for understanding pathogenesis, antibiotic resistance, and ecosystem function.
Decoding Bacterial Evolution: A Genomic Guide to Identifying Niche-Specific Adaptive Genes
This article provides a comprehensive resource for researchers and drug development professionals on the strategies and tools for identifying niche-specific bacterial adaptive genes.
Microbial Community Structure Analysis Using Metagenomics: From Foundational Concepts to Clinical and Pharmaceutical Applications
This article provides a comprehensive overview of microbial community structure analysis using metagenomics, tailored for researchers, scientists, and drug development professionals.
The Ecological Genome Project: A New Vision for One Health and Sustainable Biomedicine
This article provides a comprehensive overview of the Ecological Genome Project (EGP), an aspirational global initiative to integrate human genomic science with ecological principles through a One Health framework.
Validating Ecogenomic Signatures: From Microbial Habitats to Biomedical Applications
This article explores the validation of ecogenomic signatures—habitat-specific genetic patterns that distinguish microbial communities across environments.
Strategies for Parameter Optimization in Metagenomic Sequence Assembly: Enhancing Genome Recovery for Biomedical Research
This article provides a comprehensive guide for researchers and drug development professionals on optimizing parameters for metagenomic sequence assembly, a critical step in unlocking the functional potential of microbial communities.
Navigating Horizontal Gene Transfer in Phylogenetic Analysis: From Foundational Concepts to Advanced Detection and Clinical Application
Horizontal Gene Transfer (HGT) presents a fundamental challenge to traditional phylogenetic analysis, complicating the reconstruction of evolutionary histories and playing a critical role in the spread of traits like antibiotic...
Ecogenomics: HUGO CELS's Vision for a One Health Approach in Genomics and Drug Development
This article explores the transformative perspective of the HUGO Committee on Ethics, Law, and Society (CELS) on Ecogenomics—an interdisciplinary field that integrates genomic sciences with ecological and environmental research through...
Comparative Analysis of Niche-Associated Signature Genes: From Genomic Insights to Clinical Applications
This comprehensive review explores the identification, validation, and application of niche-associated signature genes across biological systems.