Research Articles
Navigating Horizontal Gene Transfer in Phylogenetic Analysis: From Foundational Concepts to Advanced Detection and Clinical Application
Horizontal Gene Transfer (HGT) presents a fundamental challenge to traditional phylogenetic analysis, complicating the reconstruction of evolutionary histories and playing a critical role in the spread of traits like antibiotic...
Ecogenomics: HUGO CELS's Vision for a One Health Approach in Genomics and Drug Development
This article explores the transformative perspective of the HUGO Committee on Ethics, Law, and Society (CELS) on Ecogenomics—an interdisciplinary field that integrates genomic sciences with ecological and environmental research through...
Overcoming the Hurdles: Key Challenges and Advanced Strategies in Culturing Organohalide-Respiring Bacteria
Culturing organohalide-respiring bacteria (OHRB) is pivotal for advancing bioremediation and understanding microbial ecology, yet it presents significant challenges due to their fastidious anaerobic requirements, slow growth, and complex syntrophic relationships.
Ensuring Data Integrity: A Comprehensive Guide to Pathogen Genome Quality Control Procedures
This article provides researchers, scientists, and drug development professionals with a complete framework for implementing robust quality control (QC) procedures for pathogen genome datasets.
Resolving Habitat-Associated Ecogenomic Signatures: From Microbial Tracking to Precision Medicine
This article explores the emerging field of habitat-associated ecogenomic signatures—distinct genetic patterns that reveal microbial adaptation to specific environments.
Optimizing Metagenomic Binning for Low-Abundance Species: Strategies, Tools, and Clinical Applications
Recovering genomes of low-abundance species from complex metagenomes remains a significant challenge in microbial research.
Ecogenomic Signatures in Bacteriophage Genomes: From Microbial Tracking to Precision Therapies
Bacteriophage ecogenomic signatures—distinct genetic patterns reflecting their microbial habitat—are emerging as powerful tools for diagnosing ecosystem health, tracking contamination sources, and developing precision antimicrobials.
Unlocking Microbial Dark Matter: A Guide to High-Throughput Sequencing in Modern Ecology
High-throughput sequencing (HTS) has revolutionized microbial ecology, moving research beyond mere cataloging to functional and mechanistic insights.
Microbial Ecogenomics: Unlocking Bioremediation of Chlorinated Pollutants
Chlorinated organic compounds represent a significant global environmental threat.
Environmental DNA Bioinformatics Pipelines: A Comprehensive Guide for Biomedical Researchers
This article provides a comprehensive overview of environmental DNA (eDNA) bioinformatics pipelines, tailored for researchers, scientists, and drug development professionals.